Why Schizophrenia Needs a New Definition Rooted in Biology
- Dec 16, 2025
- 4 min read
Updated: Dec 29, 2025
Written by Jonathan Dubrulle, Healer-Influencer
Jonathan Dubrulle is a Healer-Influencer in Madrid who likes to help people create 'paso a paso' a better life.
As a number 1 on Amazon in Psychiatry and Mental Health, and a schizophrenic, I wanted you to offer my insights regarding schizophrenia and plead for it to be classified only based on biological markers. Do you want to learn what the real deal schizophrenia is about?
What is currently considered schizophrenia?
In the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR), the latest version of the bible of psychiatry, to be considered schizophrenia, you need to have two or more of the following 5 core symptoms, for at least a month:
Delusions
Hallucinations
Disorganized Speech
Disorganized behavior
Diminished emotional expression
There are more criteria related to functioning, as people with the above symptoms will struggle to work, or do a full-time study or job.
The biological process?
Schizophrenia is a genius deal wherein people learn too fast in a way that results in a collapse. Based on my insights, schizophrenia is genetic. It starts in adulthood with people learning at a pace that makes grey matter explode above 2% of the total brain.
However, that pace of learning becomes impossible to manage for the brain and will result in delusions.
The solution is antipsychotics, as they reduce grey matter and the pace of learning to a more manageable level for the neocortex.
Injections, like my Xeplion, are better than pills as the management is more stable over time, with a more stable dose of Invega in the bloodstream.
Solution: An MRI diagnostic
The incidence and prevalence will be lower than currently claimed, but in my opinion, 0.1% of people have the biological version, which should only be called schizophrenia. The psychological cases shouldn’t be.
A brain scan will show increased grey matter before treatment, and a very low one after treatment. If antipsychotics don’t work in months, it is not schizophrenia, but for example bipolar, or one of the many other classifications in DSM.
Managing schizophrenia is managing the pace of learning
Schizophrenia has to be managed through medication. The pace of learning by the brain has to be managed by the neocortex, which is more developed in some people than others. Hence, schizophrenia presents itself differently in high-IQ people.
A beautiful hippocampus can also help, as people, even with schizophrenia, will behave more beautifully, even with the too fast learning disorder.
The solution is the reduction of grey matter, the learning cells in the brain, to manageable levels with antipsychotics.
A historic case of an explosion of schizophrenia after a famine in the Netherlands is explained as people learned essential things for the brain so quickly that the too-fast evolution resulted in mental illness and functional issues.
Lifelong management
The brain pattern of learning too fast naturally is almost always lifelong, with a love for learning, and requires a manageable level of grey matter, so that the processing of information can be managed by the analytical part of the brain.
Maintaining the analytical part of the brain is a good strategy to keep the processing flow of new information beautifully done by the critical elements of the neocortex.
People often get angry or traumatized with schizophrenia, as they get things too well, and find it hard to accept the exceptionally bad behavior of others during childhood, arrest, and treatment.
Softening in a psychiatric hospital can be vital for that process. That is why I am going back, when I have the opportunity, and a beautiful space has opened up.
MENtal health: Take it like a man
If you want to learn more about my life, you can always buy my book ‘MENtal Health: Take it like a man’ on Amazon. It includes my biographical chapter, rationally written.
It was number 1 in new releases in the US in the categories ‘Sexual’ and ‘Psychiatry & Mental Health’, and top 20,000 book in the overall sales rank.
Good luck with the read! And thank you, Sierra Melcher, of Red Thread Books, for bringing us all together and creating a beautiful cover.
Read more from Jonathan Dubrulle
Jonathan Dubrulle, Healer-Influencer
I’m Jonathan (38y) and a Spinal Flow Practitioner in Madrid. I started as a high-potential at Thomson Reuters when I was 21. After Brussels and Geneva, I started the healing journey in Singapore and fell in love with my Chiropractor. I discovered I was gay in a country where it was still illegal at the time. With a broken heart, I moved to New York City, where I worked in Corporate Strategy. At 24, a revolt of the soul would happen at the Times Square Headquarters, and I was admitted to Bellevue Hospital. Now I have a practice in the center of Madrid. I help clients heal and grow, develop good microhabits, and create strategies to impact the world. Beauty can rise out of ashes.
