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The Neuroscience Of Loneliness – Understanding The Science Behind The Feeling

Written by: Dr. Sydney Ceruto, Executive Contributor

Executive Contributors at Brainz Magazine are handpicked and invited to contribute because of their knowledge and valuable insight within their area of expertise.


Loneliness is a universal feeling that is experienced by everyone at some point in their lives. It can be caused by various factors, including social isolation, losing a loved one, or feeling disconnected in a crowded place. In recent years, researchers have been exploring the neuroscience of loneliness to better understand how it affects the brain and body.

Young sad teenage girl feeling lonely at school

The Science of Loneliness

When we experience loneliness, our brains activate the same regions that are associated with physical pain. This is because social and physical pain are processed in the same brain areas, such as the anterior cingulate cortex and insula. This suggests that loneliness is a type of social pain that is processed similarly to physical pain.

Furthermore, loneliness can have long-term effects on the brain. For example, chronic loneliness can decrease grey matter in the prefrontal cortex, which is associated with decision-making and social behavior. It can also lead to increased activity in the amygdala, which is associated with the processing of negative emotions.

The Physical Effects of Loneliness

Loneliness is not just a feeling; it can also physically affect the body. Chronic loneliness is associated with various health problems, including an increased risk of heart disease, depression, and premature death. This is because loneliness can lead to chronic stress, weakening the immune system and increasing inflammation in the body.

Coping with Loneliness

While loneliness can be difficult to cope with, there are ways to manage it. For example, social support can be a powerful tool in reducing feelings of loneliness. This can come from various sources, including friends, family, and online communities. Other strategies include mindfulness practices, exercise, and volunteering.

The Evolutionary Purpose of Loneliness

Loneliness has evolved as a protective mechanism for humans. When our ancestors lived in small groups, being isolated from the group could be dangerous, as it increased the risk of predation and decreased the chances of finding food or a mate. Therefore, feeling lonely could be seen as a signal to the brain that something was wrong and that action needed to be taken to reconnect with the group.

The Role of Social Media in Loneliness

In today's digital age, social media has become many people's primary source of social connection. However, research has shown that excessive social media use can lead to loneliness and social isolation. This is because social media can create a false sense of connection without the same level of emotional intimacy and social support that is present in face-to-face interactions.

The Connection between Loneliness and Mental Health

Loneliness is closely linked to mental health, particularly depression, and anxiety. Research has shown that lonely people are more likely to develop depressive symptoms and have an increased risk of suicide. This is because loneliness can lead to negative thoughts and feelings, which can be challenging to manage without social support.

Loneliness in the Workplace

Loneliness can also be a significant issue in the workplace, particularly for remote workers and those who work from home. Without the social connections that are present in an office environment, remote workers may struggle to build relationships with colleagues and feel isolated. This can lead to decreased productivity and a decrease in overall job satisfaction.

Strategies for Coping with Loneliness

In addition to the strategies mentioned earlier, there are several other ways to cope with loneliness. These include engaging in hobbies and activities that bring joy, practicing self-compassion, and seeking professional help if needed. It's important to remember that feeling lonely is a normal human experience, and many strategies are available to help manage the feeling and improve overall well-being.


In summary, loneliness is a complex feeling with various physical and mental effects. By understanding the neuroscience of loneliness, we can better understand how it affects the brain and body. This can help us develop effective strategies for coping with loneliness and improving our overall well-being.

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Dr. Sydney Ceruto, Executive Contributor Brainz Magazine

Dr. Sydney Ceruto has completed her doctoral education in the field of Cognitive & Behavioral Neuroscience & is a leading specialist in using your brains natural ability to change neuroplasticity to ensure you reach your desired goals. Her specialty is in helping clients recognize their faulty thinking patterns, change undesirable behaviors, developmental & emotional resiliency, & gain mental clarity.

When Dr. Ceruto was a teenager, she tragically lost both parents. As an only child, the loss of family completely broke her. She became profoundly depressed & began suffering from chronic anxiety. Sydney felt lost, & any form of happiness, confidence, or clarity seemed a long way off. Soon after, she began to pursue her education in medicine at Yale & obtained three masters in psychology & two Ph.D.’s in both cognitive & behavioral neuroscience at NYU. Studying the mind-brain connection was indeed the paradigm for her healing & growth. Dr. Sydney Ceruto created MindLAB Neuroscience over two decades ago. She pioneered an integrative approach based on hard science that has genuinely changed the way people make positive &, more importantly, permanent changes in all areas of their lives. Her program is highly venerated & has debunked all the myths regarding the efficacy of “traditional therapy” & the sad misnomer that you need to be on a counselor’s couch for years or even decades. Several publications have Dr. Sydney Ceruto on staff as a senior writer. She is a proud member of the Forbes Executive Council, Positive Performance Alliance, Wharton Executive Education Program, and Executive Writer for Alternatives Watch and Brainz Magazine. She has an avid intellect, a keen understanding of human nature, & an uncanny ability to connect deeply with clients. Dr. Ceruto is hands-on, accessible, highly intuitive, compassionate & is told … pretty funny!

One of her passions is traveling, which she has done extensively. Dr. Ceruto is an avid sports enthusiast and watches everything from football to Formula 1 racing. She plays golf whenever she can and enjoys exploring other cultures. Dr. Ceruto has one son who graduated from Princeton University and is studying to become a corporate attorney. She also has an affinity for animals and is an adoring mom to her 1.5-pound Micro Cuban Chihuahua, Lolita.



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